Mojgan Hodaie, MD MSc FRCS(C)

Mojgan Hodaie is staff neurosurgeon at the Toronto Western Hospital with subspecialty training in stereotactic and functional neurosurgery and the surgical co-director of the Joey and Toby Tanenbaum Family Gamma Knife Centre at the Toronto Western Hospital. Dr. Hodaie’s research focuses primarily on structural MRI imaging in functional neurosurgery, with a special focus in neuropathic pain. She has published key papers in the area focusing on methods of small fiber tractography and structural neuroanatomical changes in the CNS gray and white matter in facial neuropathic pain.

Current lab projects include:

1. Gray and white matter CNS changes associated with facial neuropathic pain: How is pain from a peripheral source represented in the brain? We attempt to answer this question using structural imaging techniques including cortical thickness analysis, voxel based morphometry and white matter analysis. We use trigeminal neuralgia – a unique form of neuropathic pain as a model for this study.

2. Development of new models and techniques in tractographic analysis of fine white matter fibers: This project deals primarily in technical development and fine tuning of tractography methods and their application to different projects within functional neurosurgery and visualization of white matter. Projects in this section and above are supported by a CIHR operating grant (2013-2018)

3. Neuroimaging correlates of pain in multiple sclerosis (MS) patients with trigeminal neuralgia: MS is a disease characterized by the formation of plaques in the CNS white matter. Patients with MS are at much higher likelihood to develop trigeminal neuralgia, a devastatingly painful condition. The pathophysiology in MS related trigeminal neuralgia differs from classic trigeminal neuralgia, we use imaging methods to determine whether we can distinguish between these two disorders, towards the development of neuroimaging correlates of pain. This work is supported by a Multiple Sclerosis Society of Canada operating grant (2013-2016)

4. Cranial nerve tractography: The Hodaie lab published the seminal article demonstrating the feasibility of detailed imaging of the course of the cranial nerves in the posterior fossa and the method in which these relate to tumors that arise there, particularly acoustic neuromas. We are linking three modalities of study: i) cranial nerve tractography, ii) tumor volumetrics and three-dimensional analysis of the tumor and iii) how these imaging techniques relate to treatment effects. These projects are supported by grants from Elekta© and Mitacs.